With its impressive hospitality and award-winning service, you’ll love the numerous amenities that can be found here at one of the finest San Diego casino hotels. Image courtesy of San Diego’s only non-smoking casino, the Barona Resort & Casino is a welcome breath of fresh air. But whatever you do, have fun! Barona Resort & Casino The rest on our list are between 40 – 6o miles from the airport. Barona is the next-closest, at a little over 30 miles from the airport and the same distance from La Jolla Cove. If you’re looking for the closest resort casino to San Diego, try Sycuan it’s about 15 miles from the airport and about 21 miles from La Jolla Cove. If you’re wanting to start your very own flirtation with Lady Luck herself - and you’re currently wondering, “What are the best casinos in San Diego?” - then why not check out these seven amazing casino hotels, found right here on our very own California coast? How This Post is Organizedįor ease of browsing, we put these in alphabetical order. Nevertheless, gambling is a game of chance, and you do need to play in order to be able to win. While we’re not going to go as far as to say that everyone’s going to hit the jackpot while gambling in our San Diego casino hotels, we will say that if you’ve decided to make our city your vacation destination, then you’re already a winner. The Best Hotel Casinos in San Diego, CA.